2460
2460, founded in 2025 and headquartered in San Francisco, California, is a Delaware C-Corporation focused on addressing operational inefficiencies in the U.S.
Profile
Operational infrastructure for organ donation and transplant.
2460, founded in 2025 and headquartered in San Francisco, California, is a Delaware C-Corporation focused on addressing operational inefficiencies in the U.S. organ donation and transplant system. The company emerged in response to a decline in deceased organ donations, which fell from 16,988 donors in 2024 to 16,550 in 2025, despite significant federal investments in clinical technologies. 2460 argues that the gap between potential and actual organ donors is not a clinical issue but an operational one, stemming from fragmented workflows and uncoordinated interfaces between Organ Procurement Organizations (OPOs) and hospitals. The company aims to build an operational layer that facilitates coordination across these entities, leveraging federal data and financial rules to streamline processes. 2460’s thesis is supported by research indicating that hospital-level conversion rates for organ donations vary widely, even within the same OPO service areas, highlighting the need for standardized operational protocols.
The company has published working papers, including 'The Coordination Layer' and 'The Organ Procurement Staffing Crisis,' to articulate its vision and advocate for systemic reforms. As of 2026, 2460 is focused on developing its Meira platform, designed to address these coordination challenges and improve donor conversion rates.
Who buys this
- Organ Procurement Organizations (OPOs)
- Hospitals with transplant programs
- Federal healthcare regulators
- Healthcare IT providers
- Non-profit organ donation advocacy groups
Strengths and what to watch
Strengths
- Focuses on a critical, underserved operational gap in organ donation.
- Backed by research and working papers that articulate systemic issues.
- Leverages federal data and financial rules to build scalable solutions.
Watch for
- Dependence on federal regulatory changes for adoption.
- Potential resistance from established OPOs and hospitals.
- Unproven scalability of the Meira platform in diverse healthcare settings.
Recent moves
Key Information
- Founded
- 2025
- Headquarters
- San Francisco, California
Frequently Asked Questions
What does 2460 do in the organ donation system?
2460 builds operational infrastructure to streamline organ donation and transplant processes. Founded in 2025, it addresses coordination gaps between Organ Procurement Organizations and hospitals. The company focuses on standardizing workflows to improve donor conversion rates, leveraging federal data and financial rules to create systemic efficiencies.
Why are organ donation rates declining despite medical advances?
2460's research shows the decline stems from operational, not clinical, issues. Fragmented workflows between hospitals and OPOs create inefficiencies. Data reveals wide variation in conversion rates even within the same service areas, indicating a need for better coordination protocols rather than improved medical technology.
How does 2460's Meira platform help with organ donation?
Meira is 2460's coordination platform designed to bridge operational gaps between OPOs and hospitals. It standardizes donation workflows, leverages federal data, and aligns with financial rules to increase donor conversion rates. The system aims to reduce inefficiencies that currently limit transplant opportunities.
Who uses 2460's organ donation solutions?
2460 serves Organ Procurement Organizations, hospitals with transplant programs, and federal healthcare regulators. Their solutions also interest healthcare IT providers and non-profit advocacy groups. The platform targets entities involved in the end-to-end organ donation process seeking operational improvements.
What challenges does 2460 face in improving transplant systems?
2460 must navigate regulatory dependencies and potential resistance from established OPOs and hospitals. The Meira platform's scalability across diverse healthcare settings remains unproven. Success requires both technological adoption and systemic workflow changes among traditionally siloed stakeholders.
How does CMS policy affect organ donation coordination?
CMS's 2026 patient protection rules reinforce accountability in organ donation systems, creating regulatory tailwinds for 2460's approach. The company leverages such federal guidelines to design its coordination layer, aligning operational improvements with evolving healthcare policy frameworks.
Sources
- www.cms.gov — CMS guidance reinforcing safeguards in organ donation.
- www.2460.life — 2460's mission and operational focus.
- aopo.org — Decline in U.S. organ donations in 2025.
- www.networkforhope.org — Context on organ donation advocacy and challenges.